Secretory Leucoprotease Inhibitor Impairs Toll-Like Receptor 2- and 4-Mediated Responses in Monocytic Cells
- 1 June 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (6), 3684-3687
- https://doi.org/10.1128/iai.72.6.3684-3687.2004
Abstract
Secretory leucoprotease inhibitor (SLPI) is an anti-inflammatory antiprotease which can inhibit lipopolysaccharide-induced NF-κB activation. We examined its ability to inhibit NF-κB activation induced by lipoteichoic acid and investigated the effects of oxidation or complex formation with neutrophil elastase on SLPI's anti-inflammatory properties in U937 myelomonocytic cells and macrophages.Keywords
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