Glutamic oxalacetic transaminase (GOT) and lactic dehydrogenase (LDH) activities

Abstract

The LDH activity was increased in the cerebrospinal fluid of all 16 brain tumor (T) patients studied. The highest levels were present in patients with malignant T. GOT activity was increased in 9 patients. Homogenates of benign or malignant T had more GOT and LDH activities than normal human brain tissue preparations on a fresh weight basis but much less per gram of protein. T contained considerably more soluble protein than brain tissue. The elevations of cerebrospinal fluid enzyme activities which occurred in the patients with brain T are not fully explained by enzyme concentrations, The origin of the additional cerebrospinal fluid enzyme remains uncertain. Preliminary electrophoretic studies were carried out on T homogenates and cyst fluid.