Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II
- 28 March 2008
- journal article
- special perspectives
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 319 (5871), 1791-1792
- https://doi.org/10.1126/science.1150843
Abstract
Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation.Keywords
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