Microvascular Thrombosis Models in Venules and Arterioles In Vivo
- 5 April 2005
- journal article
- review article
- Published by Wiley in Microcirculation
- Vol. 12 (3), 259-274
- https://doi.org/10.1080/10739680590925664
Abstract
Platelets are intimately involved in hemostasis and thrombosis. Under physiological conditions, circulating platelets do not interact with microvascular walls. However, in response to microvascular injury, platelet adhesion and subsequent thrombus formation may be observed in venules and arterioles in vivo. Numerous intravital video microscopy techniques have been described to induce and monitor the formation of microvascular thrombi. The mechanisms of microvascular injury vary widely among different models. Some models induce platelet activation with minimal effects on endothelium, others induce endothelial inflammation or injury, while other models lead to thrombus formation associated with endothelial denudation. The molecular mechanisms mediating platelet–vessel wall adhesive interactions differ among various models. In some instances, differences in responses between venules and arterioles are described that cannot be explained solely by hemodynamic factors. Several models for induction of microvascular thrombosis in vivo are outlined in this review, with a focus on the mechanisms of injury and thrombus formation, as well as on differences in responses between venules and arterioles. Recognizing these characteristics should help investigators select an appropriate model for studying microvascular thrombosis in vivo.Keywords
This publication has 100 references indexed in Scilit:
- Orally administered heparins prevent arterial thrombosis in a rat modelThrombosis and Haemostasis, 2004
- Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expressionThrombosis and Haemostasis, 2003
- Endogenous Nitric Oxide and Prostaglandins Synergistically Counteract Thromboembolism in Arterioles but Not in VenulesArteriosclerosis, Thrombosis, and Vascular Biology, 2001
- Apolipoprotein E Inhibits Neointimal Hyperplasia after Arterial Injury in MiceThe American Journal of Pathology, 2000
- Blood Platelets: An OverviewJournal of Reconstructive Microsurgery, 1989
- Platelet aggregation in partially obstructed vessels and its elimination with aspirin.Circulation, 1976
- A Comparison of Vascular Smooth Muscle Reactivity, Thrombus Formation and Fragility in Response To Electrical Stimuli in the Hamster Cheek Pouch and MesocaecumAngiology, 1965
- White Thromboembolism in the Hamster Cheek Pouch after Trauma, Infection and NeoplasiaCirculation, 1951
- MICROSCOPICAL OBSERVATIONS ON THE CIRCULATION OF THE BLOOD IN THE CEREBRAL CORTEXBrain, 1925
- Ueber einen neuen Formbestandtheil des Blutes und dessen Rolle bei der Thrombose und der BlutgerinnungVirchows Archiv, 1882