Nude Mouse Embryo: Ectodermal Nature of the Primordial Thymic Defect
- 1 March 1975
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 4 (2), 193-196
- https://doi.org/10.1111/j.1365-3083.1975.tb02616.x
Abstract
Sterile female homozygous nude mice were rendered fertile through a graft of thymic epithelium from heterozygous littermates 3 days after birth. Homozygous nude embryos were compared with embryos age (8-18 days). In nude mice, the embryological anomaly is noticeable from the 11th day of gestation and essentially consists of a failure of the ectoderm from the 3rd branchial cleft to proliferate and differentiate into a cervical vesicle. As a result, the endoderm from the 3rd pouch degenerates into cystic formations instead of differentiating.Keywords
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