Adenosylmethionine Elevation in Leukemic White Blood Cells
- 6 August 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 149 (3684), 644-645
- https://doi.org/10.1126/science.149.3684.644
Abstract
White blood cell preparations from patients with chronic myelocytic leukemia have more S-adenosylmethionine, an important metabolic intermediate, than normal peripheral white cells or thoracic-duct lymphocytes. The previously reported elevation of cyanocobalamine (vitamin Bl2) in the serum of patients with this disease is corroborated. The possible usefulness of methylation antimetabolites in cancer chemotherapy is suggested.Keywords
This publication has 7 references indexed in Scilit:
- THE FUNCTION OF VITAMIN B12 AND FOLIC ACID COENZYMES IN MAMMALIAN CELLS*Medicine, 1964
- Glycogen metabolism of normal and leukemic leukocytesLife Sciences, 1964
- Assay of tissue levels of S-adenosylmethionineAnalytical Biochemistry, 1963
- Biochemistry of Cancer (Metabolic Aspects)Annual Review of Biochemistry, 1963
- Increased Dihydrofolate Reductase Activity as a Possible Basis of Drug Resistance in LeukæmiaNature, 1961
- The metabolism of the leukemic leukocyteThe American Journal of Medicine, 1960