AMINO-LIBERATION IN BROWN-NORWAY RAT

Abstract

When injected i.v. with dextran or O-hydroxyethyl derivatives of rutoside, brown Norway rats BN/Mai Pfd f exhibit a fall in the blood pressure and an increase of vascular permeability with edema formation. As the rat is genetically deprived of plasma prekallikrein and of kininogens, activation of the kinin system is not necessary either for mast-cell degranulaton or for amine release.