Effects of acute and chronic administration of phencyclidine on tyrosine hydroxylase activity in rat striatum
- 1 December 1980
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 48 (4), 289-295
- https://doi.org/10.1007/bf01250663
Abstract
Following a single dose of phencyclidine (PCP) striatal tyrosine hydroxylase (TH) activity was decreased 42% 15 min after PCP administration, but returned toward baseline levels by 45 min post-drug. Twentyfour hours after the 30th dose of PCP, TH activity remained depressed when compared to the chronic saline controls. TH activity was not further depressed 15 or 45 min after the 31st dose of PCP.This publication has 15 references indexed in Scilit:
- Phencyclidine-induced stereotyped behavior in rats: Dose response effects and antagonism by neurolepticsLife Sciences, 1979
- Phencyclidine-induced stereotyped behavior in monkeys: Antagonism by pimozideEuropean Journal of Pharmacology, 1978
- Characteristics of enzymic decarboxylation of L-threo-3,4-dihydroxyphenylserine using hog renal L-aromatic amino acid decarboxylaseBiochemical Pharmacology, 1978
- Effects of phencyclidine on [3H]catecholamine and [3H]serotonin uptake in synaptosomal preparations from rat brainBiochemical Pharmacology, 1977
- d -Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback PathwayScience, 1976
- Self-inhibition by Dopaminergic NeuronsScience, 1975
- Amphetamine-induced inhibition of tyrosine hydroxylation in homogenates of rat corpus striatumNeuropharmacology, 1975
- Apparent feedback from the caudate nucleus to the substantia nigra following amphetamine administrationNeuropharmacology, 1975
- Assay of tyrosine hydroxylase by coupled decarboxylation of dopa formed from 1-14C-l-tyrosineAnalytical Biochemistry, 1971
- Study of a New Schizophrenomimetic Drug—SernylArchives of Neurology & Psychiatry, 1959