Potassium-sparing Agents during Diuretic Therapy in Hypertension
- 26 June 1971
- Vol. 2 (5764), 739-741
- https://doi.org/10.1136/bmj.2.5764.739
Abstract
Three pharmacological agents in use as “potassium-sparing” drugs have been tested by serial measurements of total exchangeable potassium (KE) during 4 to 12 weeks of oral diuretic therapy in hypertensive subjects. Triamterene seemed ineffective in the dosage used (50 mg twice daily). Spironolactone (25 mg twice daily) reduced K loss to a considerable extent, while Slow-K (32 mEq daily) completely reversed previous KE deficits. Plasma K levels were a poor indication of degree of KE restoration.Keywords
This publication has 12 references indexed in Scilit:
- In Vivo Effect Of Potassium On Small BowelAnnals of Surgery, 1967
- TREATMENT OF CONGESTIVE HEART FAILURE WITH TRIAMTERENE.1965
- The Circumferential Small-Bowel UlcerJAMA, 1965
- Ulcerative-Obstructive Lesions of the Small IntestineJAMA, 1965
- NONSPECIFIC STENOSING ULCERATION OF THE SMALL BOWEL: A PRELIMINARY REPORT.1964
- BODY COMPOSITION IN HYPOKALEMIC FAMILIAL PERIODIC PARALYSIS*Annals of the New York Academy of Sciences, 1963
- ON THE MECHANISM OF NITRATE-INDUCED ALKALOSIS. THE POSSIBLE ROLE OF SELECTIVE CHLORIDE DEPLETION IN ACID-BASE REGULATION*JCI Insight, 1962
- Treatment of Arterial Hypertensive Disease with DiureticsArchives of Internal Medicine, 1962
- Effect of Thiazide Diuretics on Plasma Volume, Body Electrolytes, and Excretion of Aldosterone in HypertensionCirculation, 1961
- The world's children and tomorrow.1961