Hyperchlorhydria and Hyperhistaminemia in a Patient with Systemic Mastocytosis

Abstract

SYSTEMIC mastocytosis is an uncommon disease characterized by mast-cell proliferation in the skin, bones, lymph nodes and parenchymal organs. The clinical manifestations include pruritus, bone lesions, hepatosplenomegaly and urticaria pigmentosa. Episodic cutaneous flushing results from the release of histamine into the circulation.¹ Although an increased occurrence of gastroduodenal ulceration has been noted,² gastric acid secretion has been normal or low.^{3 , 4} In the following case of systemic mastocytosis, hyperhistaminemia and hyperchlorhydria were documented.Case ReportA 70-year-old man was admitted to the hospital with a 2-year history of recurrent ulcer and episodic flushing and syncope. Physical examination demonstrated dermatographism and hepatosplenomegaly. . . .