Effects of different doses of acetylsalicylic acid on renal oxygen consumption
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 37 (3), 235-241
- https://doi.org/10.3109/00365517709091488
Abstract
The aim of the present study was to examine the acute effect of acetylsalicylic acid (ASA) on renal oxygen consumption (Qo2) and renal sodium excretion (UNaV) in anaesthetized dogs. With plasma salicylic acid (SA) concentrations ranging from 200-400 microgram/ml, Qo2 increased 36% (P less than 0.05) in spite of a 16% decrease in renal blood flow. At plasma SA concentrations of 80-200 microgram/ml Qo2 was significantly increased 45 min after the onset of ASA infusion. UNaV decreased from 97.7 to 21. 5 mumol/min (P less than 0.05). Glomerular filtration rate and absolute tubular reabsorption of sodium (RNa) was unchanged. The ratio RNa/Qo2 decreased from 31.0 to 21.3 (P less than 0.05). Renal lactate uptake increased. The results are most consistent with an uncoupling affect of ASA on oxidative phosphorylation in the kidney.Keywords
This publication has 15 references indexed in Scilit:
- Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogsScandinavian Journal of Clinical and Laboratory Investigation, 1977
- Acute effects of acetylsalicylic acid on renal function in normal manEuropean Journal of Clinical Pharmacology, 1977
- Apparent reduction of endogenous creatinine clearance by salicylate treatment.BMJ, 1976
- Effects of Different Doses of Acetylsalicylic Acid on Renal Function in the DogScandinavian Journal of Clinical and Laboratory Investigation, 1976
- Relationship between renal substrate uptake and tubular sodium reabsorption in the dogAmerican Journal of Physiology-Legacy Content, 1970
- Effects of Certain Inhibitors on Renal Sodium Reabsorption and ATP Specific ActivityNephron, 1968
- Effects of cyanide, Q0, and dinitrophenol on renal sodium reabsorption and oxygen consumptionAmerican Journal of Physiology-Legacy Content, 1964
- Sodium Transport and Oxygen Consumption in the Mammalian KidneyNature, 1961
- Die Abh ngigkeit des O2-Verbrauchs der Niere von der Na-R ckresorptionPflügers Archiv - European Journal of Physiology, 1961
- RELATIONSHIPS OF PYRUVATE AND LACTATE DURING ANAEROBIC METABOLISM. I. EFFECTS OF INFUSION OF PYRUVATE OR GLUCOSE AND OF HYPERVENTILATION1JCI Insight, 1958