Degenerate perturbations of protein structure as the mechanism of anaesthetic action
- 1 December 1978
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 276 (5690), 775-779
- https://doi.org/10.1038/276775a0
Abstract
The interaction of the n-alkanols with lipid bilayers and excitable membranes shows that there is no simple correlation between conduction block and any of the perturbations of bilayer structure currently proposed as unitary mechanisms of local anaesthetic action. We propose instead that the n-alkanols act by direct interaction with target proteins to cause perturbations which depend directly on the precise structure of the alcohol.This publication has 30 references indexed in Scilit:
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