Acute distal intestinal obstruction in gnotobiotic rats
- 1 December 1977
- journal article
- research article
- Published by Springer Nature in Virchows Archiv B Cell Pathology
- Vol. 25 (1), 151-160
- https://doi.org/10.1007/bf02889429
Abstract
Summary 1. Complete mechanical obstruction of the distal small intestine was produced in gnotobiotic rats. 72 h after the operation small intestinal morphology and epithelial cell renewal were investigated proximal and distal to the site of obstruction. 2. Proximal to the site of obstruction there were minor changes in villus height, base length and in villus cell number, a large increase in depth and diameter of the crypts and an approximately threefold increase in cell renewal. 3. Distal to the site of obstruction there were no differences between the intestines of rats with obstruction and controls. 4. The apparent lack of secretion by the goblet cells and the reduced number of intraepithelial leucocytes suggest that the barrier function of the small intestine is impaired in obstruction.Keywords
This publication has 19 references indexed in Scilit:
- Analysis of the effects of food and of digestive secretions on the small intestine of the rat. 1. Mucosal morphology and epithelial replacement.Gut, 1976
- INTRAEPITHELIAL LYMPHOCYTE COUNTS IN SMALL INTESTINAL BIOPSIES FROM CHILDREN WITH DIARRHOEAActa Paediatrica, 1976
- The Effects of Alterations in Villus Shape on the Intestinal Mucosal Surface of the Albino Rat; the Relationship between Mucosal Surface Area and the CryptsDigestion, 1976
- Untersuchungen zu Funktion und Stoffwechsel der Mucosa beim mechanischen Dünndarmileus der RatteLangenbecks Archives Of Surgery, 1975
- Functional, biochemical and morphological alterations in the intestines of rats with an experimental blind-loop syndromeZeitschrift für Die Gesamte Experimentelle Medizin, 1975
- Deoxycholate depresses small-intestinal enzyme activity.Gut, 1975
- Lymphocytes and the GutDigestion, 1975
- La fonction de la muqueuse après une occlusion aiguë de l'intestin grêle du ratZeitschrift für Die Gesamte Experimentelle Medizin, 1973
- Effects on small-intestinal function and structure induced by feeding a deconjugated bile saltGut, 1973
- Bacteria, bile salts, and intestinal monosaccharide malabsorptionGut, 1971