CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia
- 1 March 1993
- Vol. 13 (3), 278-293
- https://doi.org/10.1002/syn.890130311
Abstract
Until recently, research on the neurochemical basis of affective disorders (AD) and schizophrenia (SCZ) focused on detecting postulated disturbances in presynaptic neurotransmitter release and metabolism, or postsynaptic receptor function. New insights into the molecular mechanisms involved in the propagation of neurotransmitter signals across biological membranes and in the regulation of neuronal responses have allowed the development of novel hypotheses, which may explain the altered postsynaptic neuroreceptor responsivity thought to be integral to the pathophysiology of these disorders. In this review we evaluate evidence from both basic science and clinical research implicating disturbances in postreceptor signal transduction in the pathophysiology and pharmacotherapy of AD and SCZ. Specific findings regarding potential postreceptor sites of pathophysiology are highlighted in each of these disorders, together with the growing body of data on the possible postreceptor loci of psychotropic drug action, especially lithium and antidepressants.Keywords
This publication has 108 references indexed in Scilit:
- Lithium administration modulates platelet Gi in humansLife Sciences, 1992
- Regulation of receptor expression by agonists: transcriptional and post-transcriptional controlsTrends in Neurosciences, 1991
- Studies on leukocyte β-adrenergic receptors in depression: A critical appraisalLife Sciences, 1990
- G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brainJournal of Neural Transmission, 1990
- Abnormal signal transduction: A hypothetical model for bipolar affective disorderLife Sciences, 1989
- Dopamine uptake by platelets is selective, temperature dependent and not influenced by the dopamine-D1 or dopamine-D2 receptorLife Sciences, 1988
- Lithium stimulates the binding of GTP to the membranes of PC12 cells cultured with nerve growth factorNeuroscience Letters, 1988
- Reduced Sensitivity of Lymphocyte Beta-Adrenergic Receptors in Patients with Endogenous Depression and Psychomotor AgitationNew England Journal of Medicine, 1985
- The β-adrenergic receptor in human lymphocytes: Subclassification by the use of a new radio-ligand, (±)−125iodocyanopindololLife Sciences, 1981
- Reduced PGE1 stimulated 3H-cAMP accumulation in platelets from schizophrenicsLife Sciences, 1978