Effect of Glutamate Analogues on Brain Tumor Cell Lines
- 1 October 1985
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 45 (4), 1186-1192
- https://doi.org/10.1111/j.1471-4159.1985.tb05540.x
Abstract
Glutamate analogues have been used in many different experimental approaches in neurobiology. A small number of these analogues have been classified as gliotoxic. We have examined the effect of seven glutamate analogues (five gliotoxic and two neurotoxic) on the growth and viability of four human glioma cell lines, one human medulloblastoma cell line, and one human sarcoma cell line. Aminoadipic acid and homocysteic acid predominantly affected the growth of two glioma cell lines in the presence of 4 mM glutamine. Phosphonobutyric acid predominantly affected the other two glioma cell lines and the medulloblastoma cell line in the presence of 4 mM glutamine. In medium containing no glutamine, all three analogues had marked effects on all the cell lines except the sarcoma cell line. These effects were dose dependent. We postulate that these results can in part be explained on the basis of metabolic compartmentalization.Keywords
This publication has 28 references indexed in Scilit:
- Induction of Glutamine Synthetase by Dibutyryl Cyclic AMP in C‐6 Glioma CellsJournal of Neurochemistry, 1982
- Anticonvulsant Action of Excitatory Amino Acid AntagonistsScience, 1982
- Growth and Chemotherapeutic Response in Athymic Mice of Tumors Arising from Human Glioma-derived Cell LinesJournal of Neuropathology and Experimental Neurology, 1981
- Relationship of in Vitro Morphologic and Growth Characteristics of Established Human Glioma-derived Cell Lines to Their Tumorigenicity in Athymic Nude MiceJournal of Neuropathology and Experimental Neurology, 1981
- Heterogeneity of Genotypic and Phenotypic Characteristics of Fifteen Permanent Cell Lines Derived from Human GliomasJournal of Neuropathology and Experimental Neurology, 1981
- Uptake, Release, and Metabolism of D‐ and L‐α‐Aminoadipate by Rat Cerebral CortexJournal of Neurochemistry, 1981
- ACTIONS OF l‐ AND d‐HOMOCYSTEATE IN RAT CNS: A CORRELATION BETWEEN LOW‐AFFINITY UPTAKE AND THE TIME COURSES OF EXCITATION BY MICROELECTROPHORETICALLY APPLIED L‐GLUTAMATE ANALOGUESJournal of Neurochemistry, 1977
- Pipecolic acid pathway: The major lysine metabolic route in the rat brainBiochemical and Biophysical Research Communications, 1976
- Phosphate-dependent glutaminase from rat kidneyArchives of Biochemistry and Biophysics, 1976
- Compartmentation of Amino Acid MetabolismPublished by Springer Nature ,1969