Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment
Open Access
- 1 September 2005
- journal article
- clinical trial
- Published by American Society of Hematology in Blood
- Vol. 106 (5), 1778-1785
- https://doi.org/10.1182/blood-2005-01-0143
Abstract
To elucidate interpatient variability in thioguanine nucleotide (TGN) concentrations in acute lymphoblastic leukemia (ALL) cells, we determined the TKeywords
This publication has 67 references indexed in Scilit:
- Statistical significance for genomewide studiesProceedings of the National Academy of Sciences, 2003
- Thioguanine substitution alters DNA cleavage mediated by topoisomerase IIThe FASEB Journal, 2000
- Cloning of the cDNA for the Human ATP Synthase OSCP Subunit (ATP50) by Exon Trapping and Mapping to Chromosome 21q22.1-q22.2Genomics, 1995
- Biochemical Characterization of Human GMP SynthetaseJournal of Biological Chemistry, 1995
- Red blood cell hypoxanthine phosphoribosyltransferase activity measured using 6‐mercaptopurine as a substrate: a population study in children with acute lymphoblastic leukaemiaBritish Journal of Clinical Pharmacology, 1993
- Studies Strategies and DesignJournal of Pediatric Hematology/Oncology, 1993
- Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemiaThe Journal of Pediatrics, 1991
- Molecular dosimetry of sister chromatid exchange induction in 9L cells treated with 6-thioguanineMutagenesis, 1991
- Variable Bioavailability of Oral MercaptopurineNew England Journal of Medicine, 1983
- Purine nucleoside metabolism in the erythrocytes of patients with adenosine deaminase deficiency and severe combined immunodeficiency.JCI Insight, 1976