Translation of RNAIII, theStaphylococcus aureusagr regulatory RNA molecule, can be activated by a 3′-end deletion
- 1 November 1995
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 133 (1-2), 155-161
- https://doi.org/10.1111/j.1574-6968.1995.tb07877.x
Abstract
RNAIII, an RNA molecule shown to encode δ-hemolysin and independently to regulate toxin synthesis in Staphylococcus aureus, is transcribed at the mid-exponential phase of growth, while its target genes are activated 2 h later, at the post-exponential phase of growth. We show here that the translation of RNAIII to the 26-amino acid peptide δ-hemolysin is delayed by 1 h, and that this delay is abolished when the 3′-end of this molecule is deleted. We suggest that structural changes of RNAIII to a translatable form of the molecule precede its regulation of target gene expression.Keywords
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