A significantly greater rate of "unstimulated" parotid salivary flow was observed with 14 children with cystic fibrosis of the pancreas than with 24 normal children. The concentration of sodium and chloride in mixed saliva was significantly elevated in 12 children with cystic fibrosis of the pancreas as compared with 14 normal children. The response to injection of methacholine chloride was greater for both rate of parotid flow and concentration of sodium and chloride with 10 children with cystic fibrosis of the pancreas than with 10 normal children. Concentration of potassium showed no significant difference in either group. The response elicited in the parotid by administration of methacholine chloride indicated a decreased threshold of response and consequent increased sensitivity to parasympathomimetic stimulation in the patients with cystic fibrosis of the pancreas.