A comparative study of the excretion of Fujiwara reaction-positive substances in urine of humans and rodents given trichloro- or tetrachloro-derivatives of ethane and ethylene
Open Access
- 1 January 1972
- journal article
- research article
- Published by BMJ in Occupational and Environmental Medicine
- Vol. 29 (1), 99-104
- https://doi.org/10.1136/oem.29.1.99
Abstract
Ikeda, M., and Ohtsuji, H. (1972).Brit. J. industr. Med.,29, 99-104. A comparative study or the excretion of Fujiwara reaction-positive substances in urine of humans and rodents given trichloro- or tetrachloro-derivatives of ethane and ethylene. 1,1,1-Trichloroethane, 1,1,2- trichloroethane, 1,1,1,2-tetrachloroethane, 1,1,2,2-tetrachloroethane, trichloroethylene, and tetrachloroethylene were administered to rats and mice as vapours at 200 p.p.m. for 8 hours and urine was collected for 48 hours. The urine was analysed by the Fujiwara reaction for total trichlorocompounds (TTC), trichloroacetic acid (TCA), and trichloroethanol (TCE). All compounds except 1,1,2-trichloroethane yielded substantial TCA and TCE but 1,1,1,2-tetrachloroethane and trichloroethylene much more than the rest. The results obtained during two periods of 48 hours after intraperitoneal injection were similar. The variations in the amounts of metabolites are shown to be consistent with the vapour pressures of the solvents (compounds with high vapour pressures are lost from the lungs before being metabolized) and with their known chemical properties, according to which 1,1,1-trichlorocompounds should yield TCE and TCA readily, whereas 1,1,2-chlorocompounds should not. Excretion of metabolites from men exposed intermittently to vapours of tetrachloroethylene and trichloroethylene were also studied. Both gave enough TCE and TCA, but trichloroethylene gave considerably more, in accordance with its relative instability to oxidation.Keywords
This publication has 13 references indexed in Scilit:
- Experimental Human Exposure to TrichloroethyleneArchives of environmental health, 1970
- A Method for Determination of Trichloroethanol and Trichloroacetic Acid in UrineOccupational and Environmental Medicine, 1968
- The Toxicology of 1,1,1-TrichloroethaneAnnals of Occupational Hygiene, 1968
- Metabolism of trichloroethylene in liver microsomes. II. Identification of the reaction product as chloral hydrate.1965
- Urinary Metabolites of 14C-Tetrachloroethylene in MiceNature, 1961
- The Metabolism of 1,1,1-Trichloroethane by the RatArchives of environmental health, 1960
- Toxicity of 1, 1, 1-Trichloroethane as Determined on Laboratory Animals and Human SubjectsAihaj Journal, 1958
- The enzymic oxidation of chloral hydrate to trichloroacetic acidBiochemical Pharmacology, 1958
- Notes - Preparation and Properties of Tetrachloroethylene OxideThe Journal of Organic Chemistry, 1957
- Vegetable Oil Extraction, Autoxidation Products of TrichloroethyleneJournal of Agricultural and Food Chemistry, 1955