Evolutionary families of peptidases
- 15 February 1993
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 290 (1), 205-218
- https://doi.org/10.1042/bj2900205
Abstract
The available amino acid sequences of peptidases have been examined, and the enzymes have been allocated to evolutionary families. Some of the families can be grouped together in ‘clans’ that show signs of distant relationship, but nevertheless, it appears that there may be as many as 60 evolutionary lines of peptidases with separate origins. Some of these contain members with quite diverse peptidase activities, and yet there are some striking examples of convergence. We suggest that the classification by families could be used as an extension of the current classification by catalytic type.Keywords
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