THE NAUSEA AND VOMITING FOLLOWING ADMINISTRATION OF DIETHYLSTILBESTROL

Abstract

My purpose in this paper is twofold: First, a definite relation is shown to exist between the nausea and vomiting of early pregnancy and the nausea and vomiting which frequently follows the administration of diethylstilbestrol. Second, a method is described by which diethylstilbestrol may be administered with elimination of side effects in those patients who do not tolerate the drug. RELATION OF NAUSEA OF PREGNANCY TO NAUSEA FOLLOWING DIETHYLSTILBESTROL The clinical material used for this report consists of 95 patients given diethylstilbestrol for periods ranging from three months to two years. Diagnoses include the menopause (natural, surgical and irradiation), hypo-ovarianism, dysmenorrhea, vulvovaginitis of young girls, senile vaginitis, inhibition of lactation (postpartum), menometrorrhagia and 9 cases of benign prostatic hypertrophy. As the investigation progressed it was observed repeatedly that patients who previously had experienced nausea and vomiting in excessive degrees during pregnancy also had nausea and vomiting following