THE SYNTHESIS OF DIPEPTIDES WHICH CONTAIN α-AMINONITRILES AS THEIR C-TERMINAL RESIDUES
- 5 January 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 3 (1), 1-4
- https://doi.org/10.1246/cl.1974.1
Abstract
The synthesis of some dipeptides which contain α-aminonitriles as their C-terminal residues is described. The coupling reactions of active esters of N-tritylamino acids, p-nitrophenyl esters or cyanomethyl esters, with α-aminonitriles were carried out in N,N-dimethylformamide. The N-trityl protecting groups of the reaction products were removed by acid hydrolysis without affecting their nitrile groups. In this way, glycylaminoacetonitrile acetate(8), glycyl-DL-α-aminopropionitrile acetate(10) and DL-alanylaminoacetonitrile acetate(11) were synthesized.Keywords
This publication has 3 references indexed in Scilit:
- New Methods in Peptide Synthesis. I. Tritylsulfenyl and o-Nitrophenylsulfenyl Groups as N-Protecting GroupsJournal of the American Chemical Society, 1963
- N-Tritylamino Acids and Peptides. A New Method of Peptide Synthesis1Journal of the American Chemical Society, 1956
- Synthesen zyklischer Polypeptide. c‐Tetraglycyl und c‐Hexaglycyl. Über aktivierte Ester VIIHelvetica Chimica Acta, 1956