Vitamin D: 3-Deoxy-1α-Hydroxyvitamin D 3 , Biologically Active Analog of 1α-Dihydroxyvitamin D 3
- 6 June 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 188 (4192), 1013-1015
- https://doi.org/10.1126/science.1145184
Abstract
The ability of chemically synthesized 3-deoxy-lalpha-hydroxyvitamin D3, an analog of the biologically active form of vitamin D3, (lalpha,25-dihydroxyvitamin D3), to stimulate intestinal calcium transport was assessed. The 3-deoxy analog acted significantly more rapidly than vitamin D3 and only slightly slower than lalpha,25-dihydroxyvitamin D3. Comparison of the dose-response curves of these three vitamin D derivatives emphasizes the importance of the 3beta-hydroxyl group to biological activity.Keywords
This publication has 32 references indexed in Scilit:
- Structure-function studies of the interaction of the hormonally active form of vitamin D3, 1α,25-dihydroxy-vitamin D3, with the intestineJournal of Steroid Biochemistry, 1975
- Chemical synthesis and biological activity of 3-deoxy-1α-hydroxyvitamin D3 an analog of 1α,25-(OH)2-D3, the active form of vitamin D3Biochemical and Biophysical Research Communications, 1974
- Vitamin D and its analogs. I. Synthesis of 1.alpha.-hydroxycholest-5-eneThe Journal of Organic Chemistry, 1974
- lα,25-dihydroxyvitamin D3 receptor: competitive binding of vitamin D analogsLife Sciences, 1973
- 1α-Hydroxy Derivative of Vitamin D 3 : A Highly Potent Analog of 1α,25-Dihydroxyvitamin D 3Science, 1973
- 5,6- trans -25-Hydroxycholecalciferol: Vitamin D Analog Effective on Intestine of Anephric RatsScience, 1972
- 1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue CultureScience, 1972
- Studies on calciferol metabolism I. Production of vitamin D metabolite 4B from 25-OH-cholecalciferol by kidney homogenatesBiochemical and Biophysical Research Communications, 1971
- Disturbance of Calcium Metabolism by Anticonvulsant DrugsBMJ, 1970
- A GENETIC STUDY OF FAMILIAL HYPOPHOSPHATEMIA AND VITAMIN D RESISTANT RICKETS WITH A REVIEW OF THE LITERATUREMedicine, 1958