ABSOLUTE-CONFIGURATION AND ENANTIOMERIC PURITY OF CELIPROLOL
- 1 January 1986
- journal article
- research article
- Vol. 36-2 (8), 1157-1166
Abstract
The absolute configuration of (+)-celiprolol ([.alpha.]D = +6.3.degree. in CHCl3) was established by a 9-step synthesis via the (+) (R)-acetonide of (R)-glyceraldehyde. This result was confirmed by the Cupra-A CD-spectra of the isopropyl and hydroxy analogs. The enantiomeric purity was determined by NMR analysis of the diastereomeric amide esters obtained by reaction of celiprolol with 2 mol of .alpha.-methoxy-.alpha.-trifluormethylphenylacetic acid chloride (Mosher''s reagent).This publication has 5 references indexed in Scilit:
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