Parenteral Indomethacin for Closure of the Patent Ductus Arteriosus
- 1 November 1982
- journal article
- research article
- Published by American Medical Association (AMA) in American Journal of Diseases of Children
- Vol. 136 (11), 1005-1008
- https://doi.org/10.1001/archpedi.1982.03970470049014
Abstract
• During a 19-month period, 23% of preterm infants had symptomatic patent ductus arteriosus (PDA). Intravenous indomethacin was administered to 67 infants with successful closure in 91% of the patients and in 83% of those with birth weights less than 1,000 g. No differences were found between the number of doses required and birth weight, gestational age, or age at initial therapy. Transient alterations in renal function were common after therapy, but mild renal failure occurred in only four infants. The incidence of intraventricular hemorrhage and necrotizing enterocolitis in treated infants was similar to that in the total preterm population. Cicatricial retrolental fibroplasia developed in one patient. Bronchopulmonary dysplasia occurred more frequently in infants with PDA, but a decreased incidence was found after early ductal closure. Intravenous indomethacin administration successfully effects ductal closure without major complications in preterm infants. (Am J Dis Child 1982;136:1005-1008)This publication has 19 references indexed in Scilit:
- The effect of patent ductus arteriosus on flow velocity in the anterior cerebral arteries: Ductal steal in the premature newborn infantThe Journal of Pediatrics, 1981
- 128 THE ROLE OF PATENT DUCTUS ARTERIOSUS (PDA)IN THE NEONATE WITH SEVERE RESPIRATORY DISEASE: A PROSPECTIVE STUDYPediatric Research, 1981
- Pharmacological closure of ductus arteriosus in preterm infants using indomethacinArchives of Disease in Childhood, 1980
- Increased risk of bronchopulmonary dysplasia in infants with patent ductus arteriosusThe Journal of Pediatrics, 1979
- Age-Dependent Closure of the Patent Ductus Arteriosus by IndomethacinPediatrics, 1978
- Closure of the patent ductus arteriosus with ligation and indomethacin: A consecutive experienceThe Journal of Pediatrics, 1978
- Bronchopulmonary dysplasia: Possible relationship to pulmonary edemaThe Journal of Pediatrics, 1978
- Closure of the Ductus Arteriosus in Premature Infants by Inhibition of Prostaglandin SynthesisNew England Journal of Medicine, 1976
- Pharmacologic Closure of Patent Ductus Arteriosus in the Premature InfantNew England Journal of Medicine, 1976
- Incidence and Clinical Features of Patent Ductus Arteriosus in Low-Birthweight Infants: A Prospective Analysis of 150 Consecutively Born InfantsPediatrics, 1976