Absorption Studies with A Sustained Release Tablet

Abstract

The absorption of nitroglycerine, lobeline hydrochloride, radioactive ammonium bromide, creatinine, potassium penicillin V, and dihydromorphinone hydrochloride from sustained release tablets has been investigated in cats and in man. The substances were absorbed more slowly from the sustained release tablets than from conventional tablets. With the sustained release tablet fewer side-effects were seen with dihydromorphinone and a lower utilisation of creatinine and potassium penicillin V was observed. In vitro and in vivo conformity was good where a comparison could be made