A COMPARISON OF SOME PROPERTIES OF STRAINS OF PSEUDOMONAS AERUGINOSA SENSITIVE AND RESISTANT TO QUATERNARY AMMONIUM COMPOUNDS
- 1 October 1958
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Microbiology
- Vol. 4 (5), 499-503
- https://doi.org/10.1139/m58-054
Abstract
Pseudomonas aeruginosa was adapted to grow on tryptone – glucose – yeast extract agar containing 2000 p.p.m. alkyldimethylethylbenzyl ammonium chloride (QAC-A). In germicidal trials these resistant cells could be made QAC-A sensitive by treatment with ethylenediaminetetraacetate. In Warburg studies lyophilized preparations of resistant strains were more sensitive to inhibition of substrate oxidation by QAC-A than the normal strain.It is postulated that quaternary ammonium germicide resistant strains of P. aeruginosa owe their resistance to their impermeability to QAC.Keywords
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