Evidence for the Neutral Hypothesis of Protein Polymorphism
- 6 October 1972
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 178 (4056), 56-58
- https://doi.org/10.1126/science.178.4056.56
Abstract
Data for some 400 polymorphic proteins were examined with special reference to molecular evolution, by using a statistic that depends on neither mutation rate, population structure, nor other ecological factors. The result indicates that most of these polymorphisms are maintained in a population by mutation and random genetic drift.Keywords
This publication has 24 references indexed in Scilit:
- Some invariant properties of a geographically structured finite population: distribution of heterozygotes under irreversible mutationGenetics Research, 1972
- Protein Polymorphism as a Phase of Molecular EvolutionNature, 1971
- A profile of Drosophila species' enzymes assayed by electrophoresis. I. Number of alleles, heterozygosities, and linkage disequilibrium in glucose-metabolizing systems and some other enzymesBiochemical Genetics, 1970
- Genetic Variation in the Horseshoe Crab (Limulus polyphemus), A Phylogenetic "Relic"Evolution, 1970
- Protein Polymorphism and Genic Heterozygosity in Two European Subspecies of the House MouseEvolution, 1969
- Evolutionary Rate at the Molecular LevelNature, 1968
- Diffusion models in population geneticsJournal of Applied Probability, 1964
- The Measurement of Effective Population NumberEvolution, 1963
- The mean time for absorption in a process of genetic typeJournal of the Australian Mathematical Society, 1963
- The Evaluation of Eigenvalues of a Differential Equation Arising in a Problem in GeneticsMathematical Proceedings of the Cambridge Philosophical Society, 1962