Homozygous haemoglobin D Punjab.
- 1 September 1975
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 12 (3), 269-274
- https://doi.org/10.1136/jmg.12.3.269
Abstract
A homozygote for the gene controlling Hb D Punjab is described. The diagnosis is supported by the peptide analysis of the Hb and the examination of both parents. There was no anemia or reticulocytosis but there was balanced synthesis of both the .alpha.A- and .beta.D-globin chains in reticulocytes. The O2 affinity of the hemolysate had a small but signficantly higher O2 affinity than normal. The only other abnormalities were a somewhat decreased osmotic fragility and a slight anisocytosis of the red cells.Keywords
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