Gastroesophageal dysfunction in Brachmann-de Lange syndrome
- 1 February 1992
- journal article
- case report
- Published by Wiley in American Journal of Medical Genetics
- Vol. 42 (3), 379-380
- https://doi.org/10.1002/ajmg.1320420327
Abstract
Two children with the Brachmann-de Lange syndrome and severe gastroesophageal reflux are described. Both had esophagitis, recurrent severe anemia, and one had recurrent episodes of aspiration pneumonia and clubbing. Medical treatment failed in both children. One child responded dramatically to surgery, but the other died before surgery could be attempted. Our experience and a review of the literature suggest that early recognition and surgical treatment of gastroesophageal reflux will reduce morbidity and mortality in children with this syndrome.Keywords
This publication has 3 references indexed in Scilit:
- Gastroesophageal dysfunction in cornelia de lange syndromeJournal of Pediatric Surgery, 1989
- Mortality, Pathological Findings and Causes of Death in the de Lange SyndromeActa Paediatrica, 1985
- Sixty-four patients with Brachmann-de Lange syndrome: A surveyAmerican Journal of Medical Genetics, 1985