ADENOSINE-DEAMINASE, TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE (TDT), AND CELL-SURFACE MARKERS IN CHILDHOOD ACUTE-LEUKEMIA
- 1 January 1978
- journal article
- research article
- Vol. 52 (6), 1125-1131
Abstract
The purpose of this report is to compare measurements of enzymatic activities and cell surface markers as methods of distinguishing subtypes of lymphoid leukemias of childhood. Twenty-six children aged 2-15 yr were studied. TdT activity was high in blasts from all 20 children with null or T [thymus-derived] cell acute lymphoblastic leukemia. The activity of adenosine deaminase per cell was higher (P < 0.005) and that of TdT lower (P < 0.05) in T than in null cell lymphoblasts, although there was some overlap in values. Blasts from 3 children with acute lymphoid leukemia were positive for surface-associated immunoglobulins. The neoplastic lymphoid cells from these children differed from T and null cell leukemic lymphoblasts by having low levels of TdT and adenosine deaminase activity. Measurements of adenosine deaminase and TdT may complement measurements of cell surface markers and distinguish biochemical subtypes of acute lymphoid leukemia.This publication has 10 references indexed in Scilit:
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