Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes
- 11 March 1994
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 263 (5152), 1453-1454
- https://doi.org/10.1126/science.8128231
Abstract
The gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells. Participation of the gamma subunit in more than one receptor may enable the elucidation of the mechanisms of XSCID development and lymphocyte differentiation.Keywords
This publication has 23 references indexed in Scilit:
- Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 ReceptorScience, 1993
- Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 ReceptorScience, 1993
- Cloning of the Mouse Interleukin 2 Receptor γ Chain: Demonstration of Functional Differences Between the Mouse and Human ReceptorsBiochemical and Biophysical Research Communications, 1993
- The IL-2/IL-2 receptor system: A current overviewCell, 1993
- Disruption of the murine IL-4 gene blocks Th2 cytokine responsesNature, 1993
- Cloning of the γ Chain of the Human IL-2 ReceptorScience, 1992
- Cytokine Receptors and Signal TransductionAnnual Review of Immunology, 1992
- Generation and Analysis of Interleukin-4 Deficient MiceScience, 1991
- Cytokines in T-cell developmentImmunology Today, 1991
- Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7-dependent cell line.The Journal of Experimental Medicine, 1990