Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM)
- 1 March 1989
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 81 (4), 308-310
- https://doi.org/10.1007/bf00283680
Abstract
We have studied genetic linkage between the gene for creatine kinase muscle type (CKMM) and the gene for myotonic dystrophy (DM). In a panel of 65 myotonic dystrophy families from Canada and the Netherlands, a maximum lod score (Zmax) of 22.8 at a recombination frequency (Θ) of 0.03 was obtained. Tight linkage was also demonstrated for CKMM and the gene for apolipoprotein C2 (ApoC2). This establishes CKMM as a useful marker for myotonic dystrophy.This publication has 22 references indexed in Scilit:
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