CRYPTOCOCCOSIS is a relatively rare disease, approximately 100 cases having been reported to date. It is characterized by invasion of the body by yeastlike organisms which have a special affinity for the lungs and central nervous system. Clinical manifestations are those of a subacute or chronic infection. Pathologically the response of the tissue is similar to that seen in other infectious granulomas. The disease was first described by Frothingham,1 who reported its occurrence in a horse. The first report of the disease in man is that of Stoddard and Cutler,2 who published their monograph in 1916. There have been numerous reports since that time. Some of the more recent reviews include one by Reeves, Butt and Hammack3 in 1941 and one by Voyles and Beck4 in 1946. The causative organism, Cryptococcus hominis, is widely distributed in nature as a saprophyte. It is a yeastlike organism which reproduces by budding only, without mycelial