Blocking Action of Tetraethylammonium on Lobelin-Induced Thoracic Pain

Abstract

The hypothesis is offered that specialized pain receptors exist in the visceral or parietal pleura and that TEA relieves certain types of thoracic pain by blocking these receptors. Attempts to demonstrate these receptors in lightly narcotized animals have been unsuccessful. However, it has been demonstrated that lobeline injd. intraven. into man will produce substernal burning and coughing which can be blocked by the prior injn. of TEA.