Randomized Double-Blind Comparison of a Calcium Antagonist and a Diuretic in Elderly Hypertensives
- 1 November 1999
- journal article
- other
- Published by Wolters Kluwer Health in Hypertension
- Vol. 34 (5), 1129-1133
- https://doi.org/10.1161/01.hyp.34.5.1129
Abstract
Abstract —Although diuretics are recommended for the treatment of hypertension, decreased diuretic use and increased calcium antagonist use necessitate a comparison of the efficacy of these drugs in preventing cardiovascular events. Patients ≥60 years of age with systolic blood pressure of 160 to 220 mm Hg and diastolic blood pressure P =0.923). The sex- and age-adjusted risk ratio for the nicardipine group was 0.973 (95% confidence interval, 0.514 to 1.839, P =0.932). The calcium antagonist and diuretic groups had a similarly decreased rate of cardiovascular events.Keywords
This publication has 15 references indexed in Scilit:
- Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertensionJournal Of Hypertension, 1998
- Influence of Long-term, Low-Dose, Diuretic-Based, Antihypertensive Therapy on Glucose, Lipid, Uric Acid, and Potassium Levels in Older Men and Women With Isolated Systolic HypertensionThe Systolic Hypertension in the Elderly ProgramArchives of Internal Medicine, 1998
- Shanghai trial of nifedipine in the elderlyJournal Of Hypertension, 1996
- Final Outcome Results of the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS)JAMA, 1996
- Temporal Patterns of Antihypertensive Medication Use Among Older Adults, 1989 Through 1992JAMA, 1995
- Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party.BMJ, 1992
- Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension)The Lancet, 1991
- Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic HypertensionJAMA, 1991
- MORTALITY AND MORBIDITY RESULTS FROM THE EUROPEAN WORKING PARTY ON HIGH BLOOD PRESSURE IN THE ELDERLY TRIAL*1, *2The Lancet, 1985
- Prospective study on the treatment of mild hypertension in the aged.Japanese Heart Journal, 1981