Cholinergic receptors in human brain: Effects of aging and alzheimer disease
- 1 December 1990
- journal article
- review article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 27 (4), 548-560
- https://doi.org/10.1002/jnr.490270416
Abstract
A general review of cholinergic receptors in human brain is presented. The paper focuses upon changes in normal aging brain and in Alzheimer disease. Studies from five different approaches are reported: (1) molecular biology; (2) receptor binding studies; (3) studies with specific neurotoxins; (4) immunocyto‐chemistry; and (5) PET scan. These studies document profound and characteristic differences between the normal aging and the pathological Alzheimer brain with regard to cholinergic receptor localization, distribution, and function.Keywords
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