This paper describes recent published design advances that have been made in desiccant cooling systems. In desiccant cooling cycles, the desiccant reduces the humidity of the air by removing moisture from the air. Then the temperature is reduced by other components such as heat exchangers, evaporative coolers, or conventional cooling coils. The main advantage that desiccant cooling systems offer is the capability of using low-grade thermal energy. Desiccant cooling systems for residential and commercial applications are now being used to reduce energy-operating costs. However, the initial costs are comparatively high. The focus of research for the past decade has been to develop desiccant systems with a high coefficient of performance. Recent studies have emphasized computer modeling and hybrid systems that combine desiccant dehumidifiers with conventional systems.