CONTROL OF ISOLEUCINE, VALINE, AND LEUCINE BIOSYNTHESIS, I. MULTI-VALENT REPRESSION
- 1 October 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (10), 1804-1808
- https://doi.org/10.1073/pnas.48.10.1804
Abstract
Valine, isoleucine and leucine are required for the repression of the enzymes leading to isoleucine and valine biosynthesis. This pheno-monon is called multi-valent repression. In contrast, the enzymes of the leucine pathway appear to be repressed only by leucine. The possible significance of multi-valent repression in the control of isoleucine, valine and leucine biosynthesis is discussed. A method of derepression of the enzymes in a strain prototrophic for the pathway is presented.Keywords
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