Group-Specific Component, Alphai-Antitrypsin and Esterase D in Canadian Eskimos
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 28 (5), 341-350
- https://doi.org/10.1159/000152976
Abstract
Three genetic markers, group-specific component (Gc), .alpha.1-antitrypsin, and esterase D, were examined in a population of Eskimos from Igloolik in the eastern Canadian Arctic. Gc and esterase D were found to be polymorphic. In addition to the common Gc types, an anodal variant called Gc Igloolik was found, probably identical to previously reported Gc Eskimo. Gene frequencies were Gc1: 0.6524, Gc2: 0.3373, GcIgl: 0.0104, for 338 Eskimos. Genetic types of .alpha.1-antitrypsin (Pi [protease inhibitor] types) were mostly M, with 2 MS sibs who were half Caucasian, in 170 Eskimos. Frequencies of the esterase D allele in 336 Eskimos were EsD1: 0.7083, EsD2: 0.2917. The frequencies of Gc2 and EsD2 are both higher than are found in Caucasian populations.Keywords
This publication has 11 references indexed in Scilit:
- Gene Frequencies and Linkage Data on EsD in ManHuman Heredity, 1976
- PROTEASE INHIBITORS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE - ALPHA1-ANTITRYPSIN HETEROZYGOTE CONTROVERSYPublished by Elsevier ,1976
- The red blood cell Esterase D polymorphism in Europe and AsiaHuman Genetics, 1976
- Sunshine and the geographical distribution of the alleles of the Gc system of plasma proteinsHuman Genetics, 1976
- Esterase D polymorphism: Description of the ?new? allele EsD4Human Genetics, 1976
- SERUM Pi TYPES IN SOME EUROPEAN, AMERICAN, ASIAN AND AFRICAN POPULATIONSActa Pathologica Microbiologica Scandinavica, 1968
- The polymorphism of “prealbumins” and α1-antitrypsin in human seraClinica Chimica Acta; International Journal of Clinical Chemistry, 1967
- ELECTROPHORETIC PATTERNS OF NORMAL AND VARIANT PHENOTYPES OF GROUP SPECIFIC (GC) COMPONENTS IN HUMAN SERUM1966
- Serum Types in East Greenland EskimosHuman Heredity, 1966
- A Deviating Gc TypeHuman Heredity, 1965