Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.
Open Access
- 1 April 1993
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 7 (4), 633-646
- https://doi.org/10.1101/gad.7.4.633
Abstract
The maternally expressed Drosophila gene torso (tor) is a receptor tyrosine kinase that, when activated, initiates a signal transduction cascade that is responsible for the proper differentiation of the terminal, nonsegmented regions of the embryo. l(1)pole hole, the Drosophila raf-1 serine-threonine kinase homolog, and corkscrew, a tyrosine phosphatase, have been shown previously to function in this signal transduction pathway. We have identified other products in this pathway by carrying out a mutagenesis screen for dominant suppressors of a tor gain-of-function allele. More than 40 mutations, some of which fall into seven complementation groups, have been characterized genetically. Two of these correspond to mutations in ras-1 and Son of sevenless (Sos), which also function in the sevenless and EGF receptor (Der) tyrosine kinase pathways. The phenotypes of several other Su(tor) mutations suggest that they also function in other receptor tyrosine kinase-activated pathways at different times during Drosophila development.Keywords
This publication has 50 references indexed in Scilit:
- The gene lin-3 encodes an inductive signal for vulval development in C. elegansNature, 1992
- ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSKCell, 1992
- The origin of pattern and polarity in the Drosophila embryoCell, 1992
- Signal transduction and the fate of the R7 photoreceptor in DrosophilaTrends in Genetics, 1991
- Establishment of dorsal-ventral and terminal pattern in the Drosophila embryoCurrent Opinion in Genetics & Development, 1991
- Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutantCell, 1991
- The GTPase superfamily: conserved structure and molecular mechanismNature, 1991
- A novel viral oncogene with structural similarity to phospholipase CNature, 1988
- A pupal lethal mutation with a paternally influenced maternal effect on embryonic development in Drosophila melanogasterDevelopmental Biology, 1985
- The drosophila ras oncogenes: Structure and nucleotide sequenceCell, 1984