Effect of Phosphorylated Hesperidin and Hyaluronidase on Absorption From Peritoneal Cavity of Rats.

Abstract

A study of the effect of intraperitoneally administered hyaluronidase (HA) and a HA inhibitor, phosphorylated hesperidin (PH), on absorption of a 0.9% NaCl solution from the peritoneal cavity of rats indicated that the former increases and the latter decreases the net absorption. HA, when administered to PH-treated animals abolished the effect of PH. Adrenalectomy had no effect on the action of PH. Evidence in literature, as well as data presented in this paper, indicate the possibility that the PH decreases the net absorption in untreated animals by a direct effect on permeability rather than by inhibition of HA.