Murine Recombinant lnterleukin-12 Increases the Acquisition of Allergic Contact Dermatitis in the Mouse

Abstract

Interleukin-12 (IL-12) is a heterodimeric cytokine tha thas pleiotropic effects on the immune response. We have studied the effect of recombinant IL-12 on allergic contact dermatitis in the mouse. IL-12 substantially up-regulates the induction of sensitivity to the contact allergens dinitrofluorobenzene and oxazolone.