Deep vein thrombosis: significant limitations of noninvasive tests.

Abstract
Impedance plethysmography (IPG) has a reputed sensitivity of 95% in the detection of proximal, clinical significant deep venous thrombosis (DVT). A review of the radiologic studies of 100 consecutive patients who underwent both venography and IPG showed venographic evidence of proximal DVT in 40 patients. The IPG was negative in 15 (38%) of these 40 cases. The specificity of the IPG was 83%. The predictive value of a negative study, with this 40% prevalence of DVT, was 77%. These disturbing results indicte a continuing role for venography in the workup of DVT.