MYOCARDIAL IMAGING WITH 9-[TE-123M]TELLURAHEPTADECANOIC ACID

Abstract

The distribution of radioactivity in the myocardium of rats and dogs infarcted by ligation of the left anterior coronary artery was determined after i.v. injection of 9-[123mTe]telluraheptadecanoic acid (123mTe HDA). In rats the normal myocardium concentrated radioactivity (3.7% .+-. 0.28 injected dose/g) to nearly 3 times that in the zones of infarction (1.12% .+-. 0.18 dose/g). The focal defects detected in the gamma-camera images of rats and dogs correspond well with areas of infarction identified in the excised hearts by staining with triphenyltetrazolium chloride. The distribution of radioactivity from 123mTe HDA in dog hearts sectioned at autopsy showed a linear correlation (r = 0.94) with blood flow as determined with 46Sc-labeled microspheres.