Effects of naloxone on experimentally induced ischemic pain and on mood in human subjects.
- 1 March 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (3), 1291-1294
- https://doi.org/10.1073/pnas.74.3.1291
Abstract
The hypothesis that painful stimuli activate the endogenous opionid (endorphin) system in humans was tested by examining the effect of the opiate antagonist naloxone on experimentally induced ischemic pain and on subjective mood ratings. I.v. injections of saline or naloxone hydrochloride (2 and 10 mg) were administered under double-blind conditions to 12 subjects. Naloxone did not affect the pain ratings. A significant dose-related effect of naloxone on tension-anxiety was found, suggesting that the endorphins, like exogenously administered opiates, may have antianxiety properties.This publication has 13 references indexed in Scilit:
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