Augmentation by calmodulin of Ca2+-induced tension development in saponin-treated (chemically skinned) rat uterine smooth muscle fibers
- 31 December 1980
- journal article
- research article
- Published by Biomedical Research Press in Biomedical Research
- Vol. 2 (6), 714-717
- https://doi.org/10.2220/biomedres.2.714
Abstract
The effect of calmodulin, an intracellular Ca2+ receptive protein, on tension development in saponin-treated (chemically skinned) uterine smooth muscle fibers of nonpregnant mature rats is described. The tension induced by Ca2+ was augmented by calmodulin in a dose-dependent manner at the fixed free Ca2+ concentration (pCa), and this augmentation was much greater at high Ca2+ concentrations (pCa < 5) than at low Ca2+ concentrations (pCa > 5). Free calmodulin in rat uterine smooth muscle cells may play some role in controlling tension development through interaction with intracellular free Ca2+.This publication has 4 references indexed in Scilit:
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