Electric shock titration in squirrel monkeys following administration of nantradol, levonantradol, or N-Methyl levonantradol

Abstract

The effects of some cannabinoid-related analgesics were examined in squirrel monkeys responding under a schedule of shock titration. Nantradol (0.1–0.3 mg/kg), levonantradol (0.03–0.1 mg/kg), or N-metnyl levonantradol (0.01–0.03 mg/kg) increased the level at which shock was maintained, but did not change rates of responding. Nantradol effects were not blocked by naloxone (0.3–3.0 mg/kg), but they were attenuated following daily administration of nantradol.