Distribution of HLA Antigens in a Mexican-American Population and a Comparison with Two Similar Populations from Different Geographical Locales

Abstract

The frequencies of 32 HLA antigens of the A and B series were determined in a previously unstudied population of Mexican-Americans in South Texas [USA]. The phenotype and gene frequencies for this group are presented and are contrasted with those determined in studies of Mexican/Mexican-American populations from 2 different locales. The statistically significant differences observed emphasize the need for indigenous controls when evaluating racially heterogeneous populations for disease-associated [linked] HLA antigens.