THE DISTRIBUTION OF ARSENIC IN THE TISSUES AFTER SERIAL ADMINISTRATION OF NEOARSPHENAMINE

Abstract

Dogs received 1-6 intravenous injections of neoarsphenamine at 4-day intervals. Six hrs. after the final injection the dogs were bled to death, the organs removed and analyzed for As. The quantity of As deposited in the different tissues bore no direct relationship to the quantity of neoarsphenamine introduced nor to the number of injections given. The authors conclude that distribution of As in the tissues follows a different order from that characteristic of inorganic As.